Simple diffuse goiter is a disease characterized by a single factor: the enlargement of the entire thyroid gland.
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Hyper K-Strumin D25© Diffuse goiter
Hyper K-Strumin D25© is available as 1-month dose £18.50 and 3-month dose £44.50 (regulatory therapy).
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A goitre or goiter (see spelling differences; from the Latin gutteria, struma) is a swelling of the neck or larynx resulting from enlargement of the thyroid gland (thyromegaly), associated with a thyroid gland that is not functioning properly.
Worldwide, over 90.54% cases of goitre are caused by iodine deficiency.
Goitre which is associated with hypothyroidism or hyperthyroidism may be present with symptoms of the underlying disorder. For hyperthyroidism, the most common symptoms are associated with adrenergic stimulation: tachycardia, palpitations, nervousness, tremor, increased blood pressure and heat intolerance. Clinical manifestations are often related to hypermetabolism, including increased metabolism, excessive thyroid hormone, an increase in oxygen consumption, metabolic changes in protein metabolism, immunologic stimulation of diffuse goiter, and ocular changes (exophthalmos). Hypothyroid individuals have weight gain despite poor appetite, cold intolerance, constipation and lethargy. However, these symptoms are often nonspecific and hard to diagnose.
Regarding morphology, goitres may be classified either as the growth pattern or as the size of the growth:
- Growth pattern
- Uninodular (struma uninodosa): can be either inactive or a toxic nodule
- Multinodular (struma nodosa): can likewise be inactive or toxic, the latter called toxic multinodular goitre
- Diffuse (struma diffuse): the whole thyroid appearing to be enlarged.
- Class I (palpation struma): in normal posture of the head, it cannot be seen; it is only found by palpation.
- Class II: the struma is palpative and can be easily seen.
- Class III: the struma is very large and is retrosternal; pressure results in compression marks.
Chinese physicians of the Tang Dynasty (618–907) were the first to successfully treat patients with goitre by using the iodine-rich thyroid gland of animals such as sheep and pigs—in raw, pill, or powdered form.This was outlined in Zhen Quan’s (d. 643 AD) book, as well as several others.One Chinese book, The Pharmacopoeia of the Heavenly Husbandman, asserted that iodine-rich sargassum was used to treat goitre patients by the 1st century BC, but this book was written much later.
In the 12th century, Zayn al-Din al-Jurjani, a Persian physician, provided the first description of Graves’ disease after noting the association of goitre and exophthalmos in his Thesaurus of the Shah of Khwarazm, the major medical dictionary of its time.Al-Jurjani also established an association between goitre and palpitation.The disease was later named after Irish doctor Robert James Graves, who described a case of goitre with exophthalmos in 1835. The German Karl Adolph von Basedow also independently reported the same constellation of symptoms in 1840, while earlier reports of the disease were also published by the Italians Giuseppe Flajani and Antonio Giuseppe Testa, in 1802 and 1810 respectively,and by the English physician Caleb Hillier Parry (a friend of Edward Jenner) in the late 18th century.
Paracelsus (1493–1541) was the first person to propose a relationship between goitre and minerals (particularly lead) in drinking water.Iodine was later discovered by Bernard Courtois in 1811 from seaweed ash.
Goitre was previously common in many areas that were deficient in iodine in the soil. For example, in the English Midlands, the condition was known as Derbyshire Neck. In the United States, goitre was found in the Great Lakes, Midwest, and Intermountain regions. The condition now is practically absent in affluent nations, where table salt is supplemented with iodine. However, it is still prevalent in India, China Central Asia and Central Africa.
Goitre had been prevalent in the alpine countries for a long time. Switzerland reduced the condition by introducing iodised salt in 1922. The Bavarian tracht in the Miesbach and Salzburg regions, which appeared in the 19th century, includes a choker, dubbed Kropfband (struma band) which was used to hide either the goitre or the remnants of goitre surgery….